The world passed the halfway point of oil supply in 2005. World demand for oil likely will severely outstrip supply in 2008, leading to increasingly higher oil prices. Consequences are likely to include increasing gasoline prices, rapidly increasing inflation, and subsequently a series of increasingly severe recessions followed by a worldwide economic depression. Consequences may include, particularly in industrialized countries such as the United States, massive unemployment, economic collapse, and chaos.

Alzheimer's disease is characterized by plaques of amyloid-beta peptide, cleaved from amyloid-beta protein precursor . Our hypothesis is that lifespan profiles of AD-associated mRNA and protein levels in monkeys would differ from mice and that differential lifespan expression profiles would be useful to understand human AD pathogenesis. We compared profiles of AbetaPP mRNA, AbetaPP protein, and Abeta levels in rodents and primates. We also tracked a transcriptional regulator of the AbetaPP gene, specificity protein 1 , and the beta amyloid precursor (...) cleaving enzyme . In mice, AbetaPP and SP1 mRNA and their protein products were elevated late in life; Abeta levels declined in old age. In monkeys, SP1, AbetaPP, and BACE1 mRNA declined in old age, while protein products and Abeta levels rose. Proteolytic processing in both species did not match production of Abeta. In primates, AbetaPP and SP1 mRNA levels coordinate, but an inverse relationship exists with corresponding protein products as well as Abeta levels. Comparison of human DNA and mRNA sequences to monkey and mouse counterparts revealed structural features that may explain differences in transcriptional and translational processing. These findings are important for selecting appropriate models for AD and other age-related diseases. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Of Body and Brush: The Grand Sacrifice as Text/Performance in Eighteenth Century ChinaR. Kent GuyOf Body and Brush: The Grand Sacrifice as Text/Performance in Eighteenth Century China. By Angela Zito. Chicago: University of Chicago Press, 1997. Pp. xix + 311. Hardcover $45.00. Paper $17.95.It may be best to think of the argument of Angela Zito's enormously stimulating book Of Body and Brush: The Grand Sacrifice as Text/Performance in (...) Eighteenth Century [End Page 623] China as a series of concentric circles. At its core is a careful and satisfyingly annotated translation of the chapters of the Comprehensive Rites of the Qing (Da Qing tong li) (1756) that concern the grand sacrifice, the most important ceremonial moment in the life of a Qing emperor. From her careful and original analysis of these materials, Zito is able to bring new life not only to the Qianlong Emperor himself but also to the worlds of which he was, or sought to be, the center. These included the officials who served him, the community of scholars and editors who wrote about ritual, and the people who looked to the state for models of the centering process. In so doing, she rescues the eighteenth century from the accusation that it was the "graveyard of modernity." But she also examines the nature of Chinese ritual itself, in a way that explodes Western assumptions and explores Chinese subjectivities.There are far too many implications of this book to deal with in a short review, and any choice of themes is somewhat subjective. Zito's suggestion that we refer to the community of Chinese officials as an "imperium" rather than a "bureaucracy" (à la Weber) is a convincing one that will certainly influence our narrative practice. I was most impressed, however, with what I found to be the triumphant demonstration that this book achieves of the vitality of ritual in the eighteenth century. We have always known, at some level, that ritual was important in China, but we have not always known what to do with this fact. Like contemporary undergraduates who respond with blank stares when asked if they have ever participated in a ritual (I have tried this), we have stood mute before the mountain of Chinese primary source materials dealing with ritual. In showing us a way to read ritual texts, Zito reminds us that these provided for the Chinese a way of "making manifest" (p. 79) the power of heaven in human affairs, and re-actualizing past words in present ceremonial. In short, eighteenth-century students of ritual texts were hardly antiquarians; they were actually optimists, pursuing the possibility that the realities of the golden age of the past could actually be recovered in the present. And they were not only this, of course, for Zito offers the fascinating suggestion that in a world where literacy was becoming more common, the analysts of ritual were attempting to recuperate their social and political positions as "interpreters and creators of authority" by reconnecting writing and obscure ancient ritual practice.This comment, however, is really an aside in an argument that is mainly concerned with how ritual was acted out in the eighteenth century. The details of the Grand Sacrifice—the various prostrations, placements, and profferings—are compellingly described and interpreted here. One waits—to say "breathlessly" may be a bit strong, but certainly with mounting anticipation—to see what historical associations or symbolic statements will come next in this most theatrical of imperial performances. One of the most interesting questions is whether the emperor sacrificed as a filial son—human, like the officials who surrounded him on the lower steps of the altar, or like a sage whose access to the heavenly realm was of a qualitatively different character than that of any other mortal. Of course the emperor was both, and it was the function of ritual, as Zito argues, to negotiate the differences between the two. [End Page 624]What is at stake in this volume is nothing less than an attempt to recover the mentality of those who were engaged in ritual practices. What did it mean when the emperor clothed his body in ceremonial... (shrink)

The Theory of Planned Behavior predicts that a combination of attitudes, perceived norms, and perceived behavioral control predict intentions, and that intentions ultimately predict behavior. Previous studies have found that the TPB can predict students’ engagement in plagiarism. Furthermore, the General Theory of Crime suggests that self-control is particularly important in predicting engagement in unethical behavior such as plagiarism. In Study 1, we incorporated self-control in a TPB model and tested whether norms, attitudes, and self-control predicted intention to plagiarize and (...) plagiarism behavior. The best statistical fit for the path-analytic model was achieved when a direct path from self-control to plagiarism engagement was specified. In Study 2, we added a measure of perceived behavioral control and split the measurement of norms into descriptive and injunctive components. This study found that both self-control and perceived-behavioral control additively contributed to the prediction of plagiarism and the path-analytic model achieved its best fit when direct paths from perceived norms to plagiarism behavior were specified. These studies suggest that setting strong anti-plagiarism norms, such as by the use of honor codes, and seeking to enhance students’ self-control may reduce engagement in plagiarism. (shrink)

The method of positron emission tomography (PET imaging) illustrates the circular logic popular in subtractive neuroimaging and linear reductive cognitive psychology. Both require that strictly feed-forward, modular, cognitive components exist, before the fact, to justify the inference of particular components from images (or other observables) after the fact. Also, both require a "true" componential theory of cognition and laboratory tasks, before the fact, to guarantee reliable choices for subtractive contrasts. None of these possibilities are likely. Consequently, linear reductive analysis has (...) failed to yield general, reliable, componential accounts. (shrink)

The method of positron emission tomography illustrates the circular logic popular in subtractive neuroimaging and linear reductive cognitive psychology. Both require that strictly feed-forward, modular, cognitive components exist, before the fact, to justify the inference of particular components from images after the fact. Also, both require a "true" componential theory of cognition and laboratory tasks, before the fact, to guarantee reliable choices for subtractive contrasts. None of these possibilities are likely. Consequently, linear reductive analysis has failed to yield general, reliable, (...) componential accounts. (shrink)

This article presents a network perspective on whistleblowing. It considers how whistleblowing affects, and is affected by, the preexisting distribution of power inside and outside an organization, where power is conceptualized as deriving from the network positions of the key actors. The article also highlights four characteristic features of whistleblowing: third‐party detriment, local subversion, appeal to central or external power, and reasonable expectation of concern. The feature of local subversion succinctly explains why whistleblowing is difficult. The feature of appeal to (...) central or external power highlights that contrary to the perception of a democratizing phenomenon, whistleblowing tends to redistribute discretion away from local power toward more central power. This suggests a need for caution about institutional measures to promote whistleblowing in contexts where governance is already highly centralized. (shrink)

Throughout history no mere mortal has been more revered and esteemed by so many diverse people than Abraham, great patriarch of the three enduring monotheistic religions. Yet Judaism, Christianity and Islam all agree that this man attempted to kill his own, innocent son, an act so dastardly that it would normally be judged both immoral and illegal in any civil society. Surprisingly, the scriptures of these three religious faiths praise Abraham for this very act, justifying it in very different ways, (...) but all portraying it as the paradigm of religious obedience. (shrink)

The cover image is based on the Original Article Whistleblowing and power: A network perspective by R. Guy Thomas, https://doi.org/10.1111/beer.12290. image.

The sporadic nature of Alzheimer's disease argues for an environmental link that may drive AD pathogenesis; however, the triggering factors and the period of their action are unknown. Recent studies in rodents have shown that exposure to lead during brain development predetermined the expression and regulation of the amyloid precursor protein and its amyloidogenic beta-amyloid product in old age. Here, we report that the expression of AD-related genes [APP, BACE1 ] as well as their transcriptional regulator were elevated in aged (...) monkeys exposed to Pb as infants. Furthermore, developmental exposure to Pb altered the levels, characteristics, and intracellular distribution of Abeta staining and amyloid plaques in the frontal association cortex. These latent effects were accompanied by a decrease in DNA methyltransferase activity and higher levels of oxidative damage to DNA, indicating that epigenetic imprinting in early life influenced the expression of AD-related genes and promoted DNA damage and pathogenesis. These data suggest that AD pathogenesis is influenced by early life exposures and argue for both an environmental trigger and a developmental origin of AD. (shrink)

A comment on “Editorial 37” Content Type Journal Article Pages 93-95 DOI 10.1007/s10698-011-9110-4 Authors Brian T. Sutcliffe, Laboratoire de Chimie quantique et Photophysique, Université Libre de Bruxelles, B-1050 Bruxelles, Belgium R. Guy Woolley, School of Biomedical and Natural Sciences, Nottingham Trent University, Nottingham, NG11 8NS UK Journal Foundations of Chemistry Online ISSN 1572-8463 Print ISSN 1386-4238 Journal Volume Volume 13 Journal Issue Volume 13, Number 2.

The method of positron emission tomography illustrates the circular logic popular in subtractive neuroimaging and linear reductive cognitive psychology. Both require that strictly feed-forward, modular, cognitive components exist, before the fact, to justify the inference of particular components from images after the fact. Also, both require a "true" componential theory of cognition and laboratory tasks, before the fact, to guarantee reliable choices for subtractive contrasts. None of these possibilities are likely. Consequently, linear reductive analysis has failed to yield general, reliable, (...) componential accounts. (shrink)

This paper responds to the commentaries from Stacy Carter and Alan Cribb. We pick up on two main themes in our response. First, we reflect on how the process of setting standards for empirical bioethics research entails drawing boundaries around what research counts as empirical bioethics research, and we discuss whether the standards agreed in the consensus process draw these boundaries correctly. Second, we expand on the discussion in the original paper of the role and significance of the concept of (...) ‘integrating’ empirical methods and ethical argument as a standard for research practice within empirical bioethics. (shrink)

Background: Clinical ethics support instruments aim to support healthcare professionals in dealing with moral challenges in clinical practice. CURA is a relatively new instrument tailored to the wishes and needs of healthcare professionals in palliative care, especially nurses. It aims to foster their moral resilience and moral competences. Aim: To investigate the effects of using CURA on healthcare professionals regarding their Moral Resilience and Moral Competences. Design: Single group pre-/post-test design with two questionnaires. Methods: Questionnaires used were the Rushton Moral (...) Resilience Scale measuring Moral Resilience and the Euro-MCD, measuring Moral Competences. Respondents mainly consisted of nurses and nurse assistants who used CURA in daily practice. Forty-seven respondents contributed to both pre- and post-test with 18 months between both tests. Analysis was done using descriptive statistics and Wilcoxon signed rank tests. This study followed the SQUIRE checklist. Ethical considerations: This study was approved by the Institutional Review Board of Amsterdam UMC. Informed consent was obtained from all respondents. Results: The total Moral Resilience score and the scores of two subscales of the RMRS, that is, Responses to Moral Adversity and Relational Integrity, increased significantly. All subscales of the Euro-MCD increased significantly at posttest. Using CURA more often did not lead to significant higher scores on most (sub) scales. Conclusion: This study indicates that CURA can be used to foster moral resilience and moral competences of healthcare professionals. CURA therefore is a promising instrument to support healthcare professionals in dealing with moral challenges in everyday practice. (shrink)